Crystalline Sponge Gallery

G085 · Macrocyclic polyketide

Brefeldin A

C16H24O4 · 280.36 g mol−1

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INTERACTIVE 3D STRUCTURE

Explore Brefeldin A in its crystalline sponge

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CHONCagePhenanthrene 2a
2D chemical structure of Brefeldin A
Brefeldin A · 2D chemical structure
3D crystal structure of Brefeldin A determined by the crystalline-sponge method
Brefeldin A · crystalline-sponge guest structure
Brefeldin A inside a crystalline sponge coordination cage
Brefeldin A · coordination-cage host–guest structure

Brefeldin A (compound 15) was structurally analyzed using cage 1a and phenanthrene (2a) in the size-compensation strategy for low-polarity small molecules.

Molecular formula
C16H24O4
Molecular weight
280.36 g mol−1
CCDC accession
2565734 ↗
Host
Pd6L4 cage 1a
Study
Angew. Chem. 2026 · Size compensation
Compound in publication
15

Crystal records in this study

HostModulatorCCDCSI table
Standard cage 1aPhenanthrene 2a2565734S12

SOURCE PUBLICATION

Expanding the Chemical Space of Analytes in the 2G Crystalline Sponge Method: Size-Compensation Strategy for the Structural Analysis of Low-Polarity Small Molecules

W. He, L. Soliman, H. Takezawa, M. Fujita

Angew. Chem. Int. Ed. 2026, e4748505.

First published: 20 October 2026 · Early View

DOI 10.1002/anie.4748505 ↗