Publications

Size compensation for low-polarity small molecules

Expanding the Chemical Space of Analytes in the 2G Crystalline Sponge Method: Size-Compensation Strategy for the Structural Analysis of Low-Polarity Small Molecules

Wei He, Luc Soliman, Hiroki Takezawa & Makoto Fujita

Angewandte Chemie International Edition 2026, e4748505.

First published: 20 October 2026 · Early View

Phenanthrene-assisted size compensation enabled structural analysis of 24 of 30 low-polarity C15 analytes (80%), including 11 previously unreported X-ray crystal structures.

DOI 10.1002/anie.4748505

Relative stereochemistry of flexible ring systems

Determination of the relative stereochemistry of flexible ring systems by a cage-based crystalline sponge method

Y. Yu, W. He, L. Soliman, H. Takezawa, M. Fujita

Chem. Lett. 2026, 55, upag175.

DOI 10.1093/chemle/upag175

Standardized structure analysis

Second-Generation Crystalline Sponges Enabling Consistent Structure Analysis Under Standardized Conditions for Diverse Molecules

Wei He, Hiroki Takezawa & Makoto Fujita

Angewandte Chemie International Edition 2026.

DOI 10.1002/anie.202524615

Rotaxane structure determination

Constructing chiral rotaxanes with both mechanical and macrocyclic planar chirality by enantioselective C–H activation

Bing-Jie Wang, Yao-Le Jiang, Yikuan Yu, Wei He, Yuan Xu, Tian-Yu Jiang, Hiroki Takezawa, Makoto Fujita, Qi-Jun Yao & Bing-Feng Shi

Chem 2026.

DOI 10.1016/j.chempr.2026.103211

Coordination-cage crystalline sponges

Supramolecular coordination cages as crystalline sponges through a symmetry mismatch strategy

Wei He, Yikuan Yu, Kenta Iizuka, Hiroki Takezawa & Makoto Fujita

Nature Chemistry 2025.

DOI 10.1038/s41557-025-01750-x

Capillary workflow

Host-Guest Chemistry in a Capillary Applied to the Facilitation of the Crystalline Sponge Method

Wei He, Hiroki Takezawa, Ryo Yakushiji, Satoshi Yoshida, Sota Sato & Makoto Fujita

Angewandte Chemie International Edition 2025.

DOI 10.1002/anie.202501025